Painkillers can reduce antidepressants' effect
Wednesday, May 25, 2011 at 4:21PM
Lab indicates aspirin and ibuprofen decrease effectiveness of SSLIs, including Prozac.
Painkillers such as aspirin and ibuprofen could decrease the effectiveness of certain antidepressant medications, a new study suggests.
Mice given both an anti-inflammatory drug (also called an NSAID, non-steroidal anti inflammatory drug) and a selective serotonin reuptake inhibitor (SSRI, a type of antidepressant) scored worse on a test measuring antidepressant effectiveness than mice given only the SSRI, researchers found.
SSRIs, a drug category that includes Prozac, are one ot the most widely prescribed antidepressant medications, though the treatment is not effective for everyone, said the study's lead author, Jennifer Warner-Schmidt, a researcher at the Rockefeller University in New York City.
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According to a new study, "painkillers could decrease the effectiveness of certain antidepressant medications. The researchers said the anti-inflammatory medications could counteract the antidepressants by inhibiting the production of a particular signaling protein, called p11."
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Spencer, I think you are referring to the the research conducted by Jennifer Warner-Schmidt and Paul Greengard at The Rockefeller University in New York. They actually tested the "interaction of SSRIs and NSAIDs in mice. The mice responded less well to the antidepressants when they also were given NSAIDs." buy xenical
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